| Champ: | Jiske Griffioen |
| Runner: | Aniek van Koot |
| Score: | 6–0, 6–2 |
See main article: 2015 French Open.
Jiske Griffioen defeated Aniek van Koot in the final, 6–0, 6–2 to win the women's singles wheelchair tennis title at the 2015 French Open.
Yui Kamiji was the defending champion, but was defeated in the semifinals by van Koot in a rematch of the previous year's final.