| Runner: |  Novak Djokovic |
| Score: | 4–6, 6–4, 6–3, 6–4 |
See main article: 2015 French Open.
Stan Wawrinka defeated Novak Djokovic in the final, 4–6, 6–4, 6–3, 6–4 to win the men's singles tennis title at the 2015 French Open.[1] It was his first French Open title, and second major title overall. As he did when he won the 2014 Australian Open, Wawrinka defeated the world No. 1 and world No. 2 en route to the title.[2] Djokovic was attempting to complete the career Grand Slam. The final was the only major match Djokovic lost in 2015, thus preventing him from completing the Grand Slam.
Rafael Nadal was the five-time defending champion, but lost to Djokovic in the quarterfinals. This was only Nadal's second career defeat at the French Open (the previous one being in 2009 to Robin Söderling) and ended his record win streak at the tournament of 39 matches. Nadal had won all six of his prior matches against Djokovic at the French Open. Nadal fell to world No. 10 in the rankings after the loss, his lowest position since April 18, 2005.
Roger Federer was attempting to become the first male player in the Open Era to achieve the double career Grand Slam, but lost to Wawrinka in the quarterfinals.
See main article: 2015 French Open – Men's singles qualifying.