The women's 4x100 metres relay event at the 2015 European Athletics U23 Championships was held in Tallinn, Estonia, at Kadriorg Stadium on 12 July.
| Gold | Amelie-Sophie Lederer Alexandra Burghardt Rebekka Haase Anna-Lena Freese | |
| Silver | Martina Favaretto Irene Siragusa Anna Bongiorni Johanelis Herrera Abreu  | |
| Bronze | Lena Weiss Sarah Atcho Charlène Keller Noemi Zbären |
12 July
| Rank | Name | Nationality | Reaction Time | Time | Notes | ||
|---|---|---|---|---|---|---|---|
| align=left | Amelie-Sophie Lederer Alexandra Burghardt Rebekka Haase Anna-Lena Freese | 0.180 | 43.47 | ||||
| align=left | | Martina Favaretto Irene Siragusa Anna Bongiorni Johanelis Herrera Abreu | 0.162 | 44.06 | |||
| align=left | Lena Weiss Sarah Atcho Charlène Keller Noemi Zbären | 0.167 | 44.24 | NUR | |||
| 4 | align=left | Sacha van Agt Tessa van Schagen Naomi Sedney Eefje Boons | 0.211 | 44.46 | |||
| 5 | align=left |  | Agata Forkasiewicz Kamila Ciba Katarzyna Sokólska Karolina Zagajewska | 0.158 | 44.54 | ||
| 6 | align=left |  | Lucie Domská Karolína Hlavatá Martina Hofmanová Lucie Koudelová | 0.136 | 44.91 | ||
| 7 | align=left |  | Jessica Östlund Matilda Hellqvist Daniella Busk Caroline Larsson | 0.151 | 44.96 | ||
| align=left |  | Sarah McCarthy Cliodhna Manning Sarah Lavin Phil Healy | 0.157 | DNF |
12 July
| Rank | Nation | Competitors | Reaction Time | Time | Notes | ||
|---|---|---|---|---|---|---|---|
| 1 | align=left | Amelie-Sophie Lederer Alexandra Burghardt Rebekka Haase Anna-Lena Freese | 0.174 | 43.62 | Q | ||
| 2 | align=left | | Sarah McCarthy Cliodhna Manning Sarah Lavin Phil Healy | 0.156 | 44.68 | NUR Q | |
| 3 | align=left | | Agata Forkasiewicz Kamila Ciba Katarzyna Sokólska Sylwia Kasjanowicz | 0.156 | 44.70 | Q | |
| 4 | align=left | | Jessica Östlund Linnea Killander Daniella Busk Caroline Larsson | 0.157 | 44.77 | q | |
| align=left |  | Milja Thureson Anna Julin Anniina Kortetmaa Riikka Kokko | 0.161 | DQ | |||
| align=left | Vera Fernandes Olimpia Barbosa Cátia Santos Rivinilda Mentai | 0.200 | DNF |
| Rank | Nation | Competitors | Reaction Time | Time | Notes | ||
|---|---|---|---|---|---|---|---|
| 1 | align=left | | Martina Favaretto Irene Siragusa Anna Bongiorni Johanelis Herrera Abreu | 0.152 | 44.16 | Q | |
| 2 | align=left | Sacha van Agt Tessa van Schagen Naomi Sedney Eefje Boons | 0.202 | 44.46 | Q | ||
| 3 | align=left | Lena Weiss Sarah Atcho Charlène Keller Noemi Zbären | 0.160 | 44.47 | NUR Q | ||
| 4 | align=left | | Lucie Domská Karolína Hlavatá Martina Hofmanová Lucie Koudelová | 0.131 | 44.74 | q | |
| 5 | align=left |  | Astrid Cederkvist Ida Bakke Hansen Agathe Holtan Wathne Marlen Aakre | 0.140 | 46.19 | ||
| 6 | align=left | Evija Šēfere Ingūna Čeiko Gunta Latiševa-Čudare Diana Daktere | 0.169 | 46.65 |
According to an unofficial count, 50 athletes from 12 countries participated in the event.