| Champ: |  Víctor Estrella Burgos |
| Runner: |  Feliciano López |
| Score: | 6–2, 6–7(5–7), 7–6(7–5) |
| Draw: | 28 |
| Seeds: | 8 |
| Type: | singles doubles |
| After Name: | Ecuador Open Quito – Singles |
| Before Year: | no |
See main article: 2015 Ecuador Open Quito. This was the first edition of the tournament.
Víctor Estrella Burgos won the title, defeating Feliciano López in the final, 6–2, 6–7(5–7), 7–6(7–5). Burgos became the oldest first-time ATP champion in the Open Era,[1] a record which would be surpassed by Paolo Lorenzi at the 2016 Generali Open Kitzbühel.[2]
The top four seeds receive a bye into the second round.
See also: 1. Feliciano López (final)
See also: 2. 
Santiago Giraldo (second round)
See also: 3. Fernando Verdasco (semifinals)
See also: 4. 
Martin Kližan (quarterfinals)
See also: 5. 
Paolo Lorenzi (quarterfinals)
See also: 6. 
Thomaz Bellucci (semifinals)
See also: 7. 
Dušan Lajović (quarterfinals)
See also: 8. Víctor Estrella Burgos (champion)
See also: 1. Thiemo de Bakker (first round)
See also: 2. 
Jason Kubler (second round)
See also: 3. 
Adrian Ungur (second round)
See also: 4. 
Gerald Melzer (qualified)
See also: 5. André Ghem (qualified)
See also: 6. Roberto Carballés Baena (qualifying competition)
See also: 7. 
Elias Ymer (first round)
See also: 8. Fabiano de Paula (second round)