See main article: 2015 Delray Beach International Tennis Championships. Marin Čilić was the defending champion, but withdrew due to injury.
Ivo Karlović won the title, defeating Donald Young in the final, 6–3, 6–3.
See also: 1. Kevin Anderson (second round)
See also: 2. 
John Isner (first round)
See also: 3. 
Alexandr Dolgopolov (quarterfinals)
See also: 4. Ivo Karlović (champion)
See also: 5. 
Adrian Mannarino (semifinals)
See also: 6. Sam Querrey (first round, retired)
See also: 7. Steve Johnson (quarterfinals)
See also: 8. 
Viktor Troicki (second round)
See also: 1. Aljaž Bedene (second round)
See also: 2. 
Victor Hănescu (qualifying competition)
See also: 3. 
Thanasi Kokkinakis (qualified)
See also: 4. 
Yoshihito Nishioka (qualified)
See also: 5. Ryan Harrison (withdrew)
See also: 6. Chase Buchanan (second round)
See also: 7. Alex Kuznetsov (qualifying competition)
See also: 8. Jared Donaldson (first round)