The 2015 Copa do Brasil Second Round was played from 22 April to 20 May 2015, to decide the 20 teams advancing to the Third Round.[1]
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----Palmeiras won 6–2 on aggregate.
----Tied 3–3 on aggregate, ASA won on away goals.
----Botafogo won 5–1 on aggregate.
----Figueirense won 2–1 on aggregate.
----Santos won 3–2 on aggregate.
----Tied 2–2 on aggregate, Sport won on penalties.
Flamengo advanced directly due to winning by 2 or more goals difference.
Náutico advanced directly due to winning by 2 or more goals difference.
----Goiás won 3–1 on aggregate.
----Ituano won 3–2 on aggregate.
----Tied 3–3 on aggregate, Coritiba won on penalties.
----Ponte Preta won 6–2 on aggregate.
----Tied 1–1 on aggregate, Vasco da Gama won on away goals.
----América de Natal won 4–3 on aggregate.
----Tied 2–2 on aggregate, Tupi won on away goals.
----Ceará won 4–1 on aggregate.
Grêmio advanced directly due to winning by 2 or more goals difference.
Criciúma advanced directly due to winning by 2 or more goals difference.
----Bahia won 3–1 on aggregate.
----Paysandu won 3–1 on aggregate.