| Date: | 10–16 August |
| Edition: | 28th |
| Location: | Aptos, California, United States |
| Champs: |  John Millman |
| After Name: | Nordic Naturals Challenger |
The 2015 Comerica Bank Challenger was a professional tennis tournament played on hard courts. It was the 28th edition of the tournament which was part of the 2015 ATP Challenger Tour. It took place in Aptos, California, United States between 10 and 16 August 2015.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Australia | John Millman | 84 | 1 | |
 Tunisia | Malek Jaziri | 85 | 2 | |
 United Kingdom | Kyle Edmund | 107 | 3 | |
| Bjorn Fratangelo | 110 | 4 | ||
 Japan | Taro Daniel | 111 | 5 | |
| Australia | Matthew Ebden | 127 | 6 | |
| Austin Krajicek | 131 | 7 | ||
| Japan | Yoshihito Nishioka | 136 | 8 |
The following players received wildcards into the singles main draw:
The following players entered into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following players received entry as a lucky loser:
See main article: 2015 Comerica Bank Challenger – Singles.
John Millman def. 
Austin Krajicek, 7–5, 2–6, 6–3See main article: 2015 Comerica Bank Challenger – Doubles.
Chris Guccione / 
Artem Sitak def. 
Yuki Bhambri / Matthew Ebden, 6–4, 7–6(7–2)