The 2015 Città di Vercelli – Trofeo Multimed was a professional tennis tournament played on clay courts. It was the second edition of the tournament which was part of the 2015 ATP Challenger Tour. It took place in Vercelli, Italy between April 20 and 26.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Serbia | ||||
| Dustin Brown | 105 | 2 | ||
| Igor Sijsling | 128 | 3 | ||
 United Kingdom | Kyle Edmund | 129 | 4 | |
 Belgium | Kimmer Coppejans | 146 | 5 | |
 Italy | Marco Cecchinato | 149 | 6 | |
| Mate Delić | 162 | 7 | ||
| Italy | Andrea Arnaboldi | 177 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
Omar GiacaloneSee main article: 2015 Città di Vercelli – Trofeo Multimed – Singles.
Taro Daniel def. Filippo Volandri, 6–3, 1–6, 6–4See main article: 2015 Città di Vercelli – Trofeo Multimed – Doubles.
Andrea Arnaboldi / Hans Podlipnik Castillo def. 
Sergey Betov / 
Michail Elgin, 6–7(5–7), 7–5, [10–3]