| Date: | 2–8 November |
| Edition: | 7th |
| Draw: | 32S/16D/32QS/4QD |
| Prize Money: | $50,000 |
| Surface: | Indoor Hard |
| Location: | Charlottesville, United States |
| Champs: |  Noah Rubin |
| Champd: | Chase Buchanan / Tennys Sandgren |
The 2015 Charlottesville Men's Pro Challenger was a professional tennis tournament played on indoor hard courts. It was the seventh edition of the tournament which was part of the 2015 ATP Challenger Tour, taking place in Charlottesville, United States from November 2 to November 8, 2015.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Tunisia | Malek Jaziri | 92 | 1 | |
 Australia | James Duckworth | 99 | 2 | |
| 101 | 3 | |||
| Ryan Harrison | 107 | 4 | ||
| Bjorn Fratangelo | 129 | 5 | ||
| Jared Donaldson | 135 | 6 | ||
| 154 | 7 | |||
 United Kingdom | 224 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry as an alternate:
The following players received entry from the qualifying draw:
See main article: 2015 Charlottesville Men's Pro Challenger – Singles.
Noah Rubin def. Tommy Paul 3–6, 7–6(9–7), 6–3[1] [2]See main article: 2015 Charlottesville Men's Pro Challenger – Doubles.
Chase Buchanan / Tennys Sandgren def. 
Peter Polansky / Adil Shamasdin 3–6, 6–4, [10–5]