| Date: | 2 November – 8 November |
| Edition: | 11th |
| Surface: | Clay |
| Location: | Guayaquil, Ecuador |
| Champs: | Gastão Elias |
| Champd: |  Guillermo Durán / Andrés Molteni |
The 2015 Challenger Ciudad de Guayaquil was a professional tennis tournament played on clay courts. It was the eleventh edition of the tournament which was part of the 2015 ATP Challenger Tour. It took place in Guayaquil, Ecuador between November 2 and November 8, 2015.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Argentina | 78 | 1 | ||
 Bosnia and Herzegovina | 80 | 2 | ||
| Argentina | Guido Pella | 85 | 3 | |
| Argentina | Facundo Argüello | 121 | 4 | |
 Spain | 123 | 5 | ||
 Brazil | Rogério Dutra Silva | 124 | 6 | |
 Belgium | Kimmer Coppejans | 127 | 7 | |
| Argentina | Carlos Berlocq | 132 | 8 |
The following players received wildcards into the singles main draw:
The following players entered the main draw as alternates:
The following players received entry from the qualifying draw:
See main article: 2015 Challenger Ciudad de Guayaquil – Singles.
Diego Schwartzman 6–0, 6–4See main article: 2015 Challenger Ciudad de Guayaquil – Doubles.
Guillermo Durán / Andrés Molteni def. Gastão Elias / Fabrício Neis 6–3, 6–4
