The 2015 CAF Confederation Cup knockout stage was played from 26 September to 29 November 2015. A total of four teams competed in the knockout stage to decide the champions of the 2015 CAF Confederation Cup.[1]
The winners and runners-up of each of the two groups in the group stage qualified for the knockout stage.
| Group | width=200 | Winners | width=200 | Runners-up |
|---|---|---|---|---|
| A |  Al-Ahly |  Étoile du Sahel | ||
| B | Zamalek | Orlando Pirates |
Knockout ties were played on a home-and-away two-legged basis. If the aggregate score was tied after the second leg, the away goals rule would be applied, and if still level, the penalty shoot-out would be used to determine the winner (no extra time would be played).[1]
The schedule of each round was as follows.[2]
| Round | First leg | Second leg | |
|---|---|---|---|
| Semi-finals | 25–27 September 2015 | 2–4 October 2015 | |
| Final | 20–22 November 2015 | 27–29 November 2015 |
In the semi-finals, the group A winners played the group B runners-up, and the group B winners played the group A runners-up, with the group winners hosting the second leg.
In the final, the order of legs was determined by a draw, held after the group stage draw (5 May 2015, 11:00 UTC+2, at the CAF headquarters in Cairo, Egypt).
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Orlando Pirates won 5–3 on aggregate.----Étoile du Sahel won 5–4 on aggregate.
See main article: 2015 CAF Confederation Cup Final. |}
Étoile du Sahel won 2–1 on aggregate.