| Champ: |  Kei Nishikori |
| Runner: |  Pablo Andújar |
| Score: | 6–4, 6–4 |
| Type: | singles doubles |
| Draw: | 48 (6 / 4) |
| Seeds: | 16 |
| Before Name: | Barcelona Open Banc Sabadell – Singles |
| After Name: | Barcelona Open Banc Sabadell – Singles |
| Main Name: | Barcelona Open (tennis) Barcelona Open |
See main article: 2015 Barcelona Open Banc Sabadell.
Defending champion Kei Nishikori successfully defended his title, defeating Pablo Andújar in the final, 6–4, 6–4, to win the singles title at the 2015 Barcelona Open.
All seeds receive a bye into the second round.