See main article: 2015 Argentina Open.
David Ferrer was the three-time defending champion, but he chose to compete in Acapulco instead.
Rafael Nadal won the title, defeating Juan Mónaco in the final, 6–4, 6–1.
See also: 1. Rafael Nadal (champion)
See also: 2. Tommy Robredo (quarterfinals)
See also: 3. Pablo Cuevas (quarterfinals)
See also: 4. Fabio Fognini (second round)
See also: 5. Leonardo Mayer (second round)
See also: 6. Jiří Veselý (first round)
See also: 7. Pablo Andújar (first round)
See also: 8. Pablo Carreño Busta (first round, retired)
See also: 1. Facundo Bagnis (qualified)
See also: 2. Facundo Argüello (qualified)
See also: 3. Roberto Carballés Baena (second round)
See also: 4. Marco Cecchinato (qualified)
See also: 5. Guido Pella (first round)
See also: 6. Nicolás Jarry (first round)
See also: 7. Marco Trungelliti (first round)
See also: 8. Gonzalo Lama (second round)