See main article: 2015 Abierto Mexicano Telcel.
Grigor Dimitrov was the defending champion, but lost to Ryan Harrison in the second round.
David Ferrer won the title, defeating Kei Nishikori in the final, 6–3, 7–5.
See also: 1. Tim Smyczek (first round)
See also: 2. Lukáš Lacko (first round)
See also: 3. Alejandro González (qualified)
See also: 4. Aljaž Bedene (qualifying competition)
See also: 5. Alejandro Falla (qualifying competition)
See also: 6. Gastão Elias (first round)
See also: 7. Jimmy Wang (qualifying competition)
See also: 8. Adrián Menéndez-Maceiras (first round)