The 2015–16 Maltese Second Division started in September 2015 and ended in May 2016. Msida Saint-Joseph F.C., Kirkop United F.C. and Żurrieq F.C. were relegated to the Maltese Third Division. Marsa F.C., Sirens F.C. and Gharghur F.C. were promoted to the Maltese First Division.
Marsa were crowned champions in the last game against Gharghur as they won 2–1.[1] Additionally, Sirens lost the Derby against Mgarr United and handed the cup to the champions Marsa.