| Women's EHF Challenge Cup | |
| Year: | 2015–16 |
| Sport: | Handball |
| Champions: | Gran Canaria |
| Runners-Up1: | Kastamonu Bld. GSK |
| Previous: | 2014–15 |
| Next: | 2016–17 |
The 2015–16 Women's EHF Challenge Cup was the 19th edition of the European Handball Federation's fourth-tier competition for women's handball clubs, running from 14 November 2015.
All draws held at the European Handball Federation headquarters in Vienna, Austria.
| Round | Draw date | First leg | Second leg |
|---|---|---|---|
| Round 3 | 22 July 2014 | 14–21 November 2015 | 15–22 November 2015 |
| Last 16 | 25 November 2015 | 8–15 January 2016 | 9–17 January 2016 |
| Quarter-final | 20–22 February 2016 | 21–28 February 2016 | |
| Semi-finals | 2–3 April 2016 | 9–10 April 2016 | |
| Final |
Teams listed first played the first leg at home. Some teams agreed to play both matches in the same venue. Bolded teams qualified into last 16.|}
a Both legs were hosted by ŽRK Aranđelovac.
b Both legs were hosted by HIFK.
c Both legs were hosted by Metraco Zaglebie Lubin.
d Both legs were hosted by Schuler Afbouwgroep/DOS.
e Both legs were hosted by HC Vardar junior.
Teams listed first played the first leg at home. Some teams agreed to play both matches in the same venue. Bolded teams qualified into quarterfinals.|}
a Both legs were hosted by Kastamonu Bld. GSK.
b Both legs were hosted by Schuler Afbouwgroep.
c Both legs were hosted by Colegio de Gaia.
Teams listed first played the first leg at home. Some teams agreed to play both matches in the same venue. Teams listed first played the first leg at home. Bolded teams qualified for the semifinals.|}
a Both legs were hosted by Gran Canaria.
b Both legs were hosted by Kastamonu Bld. GSK.
|}
Team listed first played the first leg at home.|}