| Season: | 2015–16 |
| League: | 15th Pro League |
| League Result: | 11th |
| Cup1: | 29th Hazfi Cup |
| Cup1 Result: | 1/4 |
| Cup2: | 35th AFC Champions |
| Cup2 Result: | Group stage |
| Highest Attendance: | 15,000 |
| Lowest Attendance: | 800 |
| Nextseason: | 2016-17 |
| Pattern La1: | _navyshoulders |
| Pattern B1: | _Sepahanfirstkit |
| Pattern Ra1: | _navyshoulders |
| Pattern Sh1: | _adidaswhite |
| Pattern So1: | _band_black |
| Leftarm1: | FFC900 |
| Rightarm1: | FFC900 |
| Shorts1: | 000000 |
| Socks1: | FFC900 |
| Pattern La2: | _navyshoulders |
| Pattern B2: | _Sepahansecondkit |
| Pattern Ra2: | _navyshoulders |
| Pattern Sh2: | _adidaswhite |
| Pattern So2: | _band_black |
| Leftarm2: | white |
| Rightarm2: | white |
| Shorts2: | white |
| Socks2: | white |
| Pattern La3: | _goldshoulders |
| Pattern B3: | _Sepahanthirdkit |
| Pattern Ra3: | _goldshoulders |
| Pattern Sh3: | _adidaswhite |
| Pattern So3: | _band_white |
| Leftarm3: | 000000 |
| Rightarm3: | 000000 |
| Shorts3: | FFC900 |
| Socks3: | ۰۰۰۰۰۰ |
The 2015–16 season was Sepahan's 15th season in the Pro League, and their 22nd consecutive season in the top division of Iranian Football and 62nd year in existence as a football club. They competed in the Hazfi Cup and the AFC Champions League. Sepahan was captained by Moharram Navidkia.
For recent transfers, see List of Iranian football transfers winter 2015–16.