| Mode: | Women's Basketball |
| Year: | 2015–16 |
| Team: | San Francisco Dons |
| Conference: | West Coast Conference |
| Short Conf: | WCC |
| Record: | 21 - 12 |
| Conf Record: | 9 - 9 |
| Hc Year: | 6th |
| Asst Coach1: | Blair Hardiek |
| Asst Coach2: | Shanele Stires |
| Asst Coach3: | Britinee Yasukochi |
| Champion: | WCC Tournament champions |
| Bowl: | NCAA Women's Tournament |
| Bowl Result: | first round |
The 2015–16 San Francisco Dons women's basketball team represented the University of San Francisco in the 2015–16 college basketball season. It was head coach Jennifer Azzi's sixth season at San Francisco. The Dons, members of the West Coast Conference, played their home games at War Memorial Gymnasium. They finished the season 21–12, 9–9 in WCC play to finish in sixth place. They won the WCC women's tournament and earn automatic trip to NCAA women's tournament for the first time since 1997. They lost to Stanford in the first round.
On September 15, 2016, Azzi resigned as head coach of the Dons to pursue new career opportunities.[1] She finished with a six-year record of 73–114.
[2] |-!colspan=12 style="background:#006633; color:#FFCC33;"| Exhibition|-!colspan=9 style="background:#006633; color:#FFCC33;"| Non-conference regular season|-!colspan=9 style="background:#006633; color:#FFCC33;"| WCC regular season|-!colspan=9 style="background:#006633; color:#FFCC33;"| WCC Women's Tournament|-!colspan=9 style="background:#006633; color:#FFCC33;"| NCAA Women's Tournament