| Competition: | Oberliga Niederrhein |
| Season: | 2015–16 |
| Winners: | Wuppertaler SV |
| Relegated: | MSV Duisburg II1. FC MönchengladbachRW Oberhausen IITV Kalkum-Wittlaer |
| Matches: | 306[1] |
| League Topscorer: | Philipp Goris (20 goals) |
| Attendance: | 136,769 |
| Average Attendance: | 450 |
| Prevseason: | 2014–15 |
| Nextseason: | 2016–17 |
The 2015–16 Oberliga Niederrhein was the 60th season of the Oberliga Niederrhein, one of three state association league systems in the state of North Rhine-Westphalia, covering its northwestern part. It was the fourth season of the league as a fifth level of the German football league system.
The league featured five new clubs for the 2015–16 season with TV Kalkum-Wittlaer, 1. FC Mönchengladbach, SpVg Schonnebeck and SC Düsseldorf-West promoted from the Landesliga Niederrhein while KFC Uerdingen 05 had been relegated from the Regionalliga West.
The top goal scorers:[2]
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | Philipp Goris | 1. FC Bocholt | 20 |
| 2 | Danny Rankl | KFC Uerdingen 05 TV Jahn Hiesfeld | 19 |
| 3 | Chamdin Said | Schwarz-Weiß Essen | 16 |
| Alexander Lipinski | VfR Fischeln | ||
| 5 | Kevin Weggen | MSV Duisburg II | 14 |
 Ercan Aydogmus | Wuppertaler SV | ||
| Andre Trienenjost | SV Hönnepel-Niedermörmter | ||
| Boran Sezen | Rot-Weiß Oberhausen II | ||
| 9 |  Keisuke Ota | SC Kapellen-Erft | 13 |
| 10 | Stefan Schaumburg | VfB 03 Hilden | 12 |
| Kevin Breuer | VfR Fischeln |
The runners-up of the two divisions of the Landesliga Niederrhein compete for one more spot in the Oberliga.[3] |}