| Competition: | Mittelrheinliga |
| Season: | 2015–16 |
| Winners: | Bonner SC |
| Relegated: | Alemannia Aachen IIVfL LeverkusenSV BreinigSV 1914 Eilendorf |
| Matches: | 240 |
| League Topscorer: | Bayram Ilk (28 goals) |
| Attendance: | 48,926[1] |
| Average Attendance: | 210 |
| Prevseason: | 2014–15 |
| Nextseason: | 2016–17 |
The 2015–16 Mittelrheinliga was the 60th season of the Mittelrheinliga, one of three state association league systems in the state of North Rhine-Westphalia, covering its southwestern part. It was the fourth season of the league as a fifth level of the German football league system.
The league featured five new clubs for the 2015–16 season with SpVg Wesseling-Urfeld, SV Breinig, Blau-Weiß Friesdorf and TV Herkenrath promoted from the Landesliga Mittelrhein while FC Hennef 05 had been relegated from the Regionalliga West.
The top goal scorers:[2]
| Rank | Player | Club | Goals | |
|---|---|---|---|---|
| 1 | Bayram Ilk | VfL Alfter | 28 | |
| 2 | Yannick Albrecht | SV Bergisch Gladbach 09 | 19 | |
| 3 | Sascha Engel | TSC Euskirchen | 15 | |
| 4 | Lucas Musculus | Bonner SC | 14 | |
| 5 | Benny Hoose | TSC Euskirchen | 13 | |
| Denis Wegner | FC Hennef 05 | |||
 Celal Kanli | SV Bergisch Gladbach 09 | |||
| 8 | Patrick Siebert | TSV Germania Windeck | 12 | |
| Shpend Hasani | Alemannia Aachen II | |||
| Mehmet Doğan | VfL Alfter | |||
| Thomas Schmidt | SV Breinig | |||
| 12 | Serkan Okutan | FC Hürth | 11 |