| Competition: | Liga de Fútbol Profesional Boliviano |
| Season: | 2015–16 |
| Winners: | Apertura: Sport Boys (1st Title) Clausura: Jorge Wilstermann (13th Title) |
| Relegated: | Ciclón |
| Continentalcup1: | 2017 Copa Libertadores |
| Continentalcup1 Qualifiers: | Sport Boys Jorge Wilstermann The Strongest Universitario de Sucre |
| Continentalcup2: | 2017 Copa Sudamericana |
| Continentalcup2 Qualifiers: | Bolívar Oriente Petrolero Nacional Potosí Petrolero |
| Prevseason: | 2014–15 |
| Nextseason: | 2016–17 |
The 2015–16 Liga de Fútbol Profesional Boliviano season was the 39th season of LFPB.
The number of teams for 2014–15 remains the same. Universitario (P) was relegated to the Liga Nacional B. They were replaced by the 2014–15 Liga Nacional B champion Ciclón.
| width=28 | width=185 | Team | width=50 | width=50 | width=50 | width=50 | width=50 | Relegation | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Bolívar | 92 | 69 | 161 | 88 | |||||||||
| 2 | The Strongest | 79 | 77 | 156 | 88 | |||||||||
| 3 | Jorge Wilstermann | 73 | 77 | 150 | 88 | |||||||||
| 4 | Oriente Petrolero | 76 | 68 | 144 | 88 | |||||||||
| 5 | 53 | 72 | 125 | 88 | ||||||||||
| 6 | 66 | 48 | 114 | 88 | ||||||||||
| 7 | San José | 61 | 49 | 110 | 88 | |||||||||
| 8 | 38 | 70 | 108 | 88 | ||||||||||
| 9 | 63 | 41 | 104 | 88 | ||||||||||
| 10 | Nacional Potosí | 49 | 55 | 104 | 88 | |||||||||
| 11 | Petrolero | 52 | 51 | 103 | 88 | Relegation Playoff Match | ||||||||
| 12 | Ciclón | — | 50 | 50 | 44 | Relegation to the Liga Nacional B | ||||||||
Petrolero remains at the season 2016–17 LFPB.