| Competition: | Guadeloupe Division d'Honneur |
| Season: | 2015–16 |
| Winners: | USR (1st title) |
| Relegated: | Solidarité SC Club Amical |
| Continentalcup1: | CFU Club Championship |
| Continentalcup1 Qualifiers: | USR CS Moulien |
| Matches: | 182 |
| Total Goals: | 383 |
| Biggest Home Win: | Amical Club 6-1 Club Amical Siroco 5-0 Gourbeyrienne |
| Biggest Away Win: | Club Amical 0-5 US Baie-Mahault |
| Highest Scoring: | Amical Club 6-1 Club Amical |
| Prevseason: | 2014–15 |
| Nextseason: | 2016–17 |
The 2015–16 season of the Guadeloupe Division d'Honneur is the 65th season of top-tier football in Guadeloupe. It started on 4 September 2015 and finished on 24 May 2016. CS Moulien were the defending champions, having won their 11th top tier title last season. USR won their first title this season.
At the end of last season, AS Gosier and Racing Club finished in 13th and 14th place in the league and were relegated to the Promotion d'Honneur Régionale. Taking their places were the winners and runners up from the Promotion d'Honneur Régionale, Amical Club and Gourbeyrienne.
| Team | Based | Stadium | |
|---|---|---|---|
| Amical Club | Les Abymes | Stade René Serge Nabajoth | |
| Arsenal | Petit-Bourg | ||
| Gourbeyrienne | |||
| Club Amical | Capesterre-Belle-Eau | ||
| CS Moulien | Le Moule | Stade Jacques Pontrémy | |
| Juventus SA | Sainte-Anne | Stade St. Claude | |
| L'Etoile | Morne-à-l'Eau | Stade Pierre Monnerville | |
| La Gauloise | Basse-Terre | Stade St. Claude | |
| Phare du Canal | Petit-Canal | ||
| Red Star | Baie-Mahault | ||
| Siroco | Les Abymes | ||
| Solidarité SC | Baie-Mahault | Stade Fiesque Duchesne | |
| US Baie-Mahault | Baie-Mahault | Stade Fiesque Duchesne | |
| USR | Sainte-Rose |