| Mode: | Women's Basketball |
| Year: | 2015–16 |
| Team: | DePaul Blue Demons |
| Conference: | Big East Conference |
| Short Conf: | Big East |
| Coachrank: | 17 |
| Aprank: | 20 |
| Record: | 27–9 |
| Conf Record: | 16–2 |
| Hc Year: | 30th |
| Asst Coach1: | Candis Blankson |
| Asst Coach2: | Bart Brooks |
| Asst Coach3: | Jill M. Pizzotti |
| Champion: | Big East Regular Season Champions |
| Bowl: | NCAA Women's Tournament |
| Bowl Result: | Sweet Sixteen |
The 2015–16 DePaul Blue Demons women's basketball team represented DePaul University during the 2015–16 NCAA Division I women's basketball season. The Blue Demons, led by thirtieth year head coach Doug Bruno, played their home games at the McGrath-Phillips Arena. They were members of the new Big East Conference. They finished the season 27–9, 16–2 in Big East play to win the Big East regular season title. They advanced to the semifinals of the Big East women's tournament, where they lost to St. John's. They received an at-large bid to the NCAA women's basketball tournament, where they defeated James Madison in the first round, Louisville in the second round before losing to Oregon State in the sweet sixteen.
The Blue Devils finished the 2014–15 season 27–8, 15–3 in Big East play to share the regular season title with Seton Hall. They also won the Big East tournament to earn an automatic trip to the 2015 NCAA Division I women's basketball tournament, where they lost to Notre Dame in the second round.
|-!colspan=9 style="background:#00438c; color:#F10041;"| Exhibition|-!colspan=9 style="background:#00438c; color:#F10041;"| Non-conference regular season|-!colspan=9 style="background:#00438c; color:#F10041;"| Conference regular season|-!colspan=9 style="background:#00438c; color:#F10041;"| Big East Women's Tournament|-!colspan=9 style="background:#00438c; color:#F10041;"| NCAA Women's TournamentSource:[1]
See main article: 2015–16 NCAA Division I women's basketball rankings.
| + Ranking movement Legend: ██ Increase in ranking. ██ Decrease in ranking. ██ Not ranked the previous week. RV=Received votes. | т | Tied with team above or below also with this symbol --> | Poll | Pre- Season | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9 | Week 10 | Week 11 | Week 12 | Week 13 | Week 14 | Week 15 | Week 16 | Week 17 | Week 18 | Week 19 | Final |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AP | RV | RV | RV | 23 | 18 | 16 | 17 | 25 | 24 | RV | 24 | 23 | RV | 23 | 21 | 19 | 18 | 18 | 20 | N/A | |||
| Coaches | 22 | 19 | 20 | 18 | 17 | 15 | 23 | 24 | 24 | 25т | 21 | 21 | 24 | 23 | 19 | 19 | 18 | 21 | 21 | 17 |