| Tourney Name: | Copa de la Reina de Balonmano |
| Year: | 2015–16 |
| Other Titles: | XXXVII Copa de la Reina |
| Dates: | 21–22 November (1st round) 20 February (2nd round) 15–17 April (Final8) |
| Num Teams: | 12 (1st round) 12 (2nd round) 7 (Final8) |
| Venues: | Pavillón Polideportivo de Porriño |
| Cities: | O Porriño |
| Champion Other: | Bera Bera |
| Count: | 5 |
| Second Other: | Prosetecnisa Zuazo |
| Matches: | 7 |
| Goals: | 328 |
| Previous: | 2015 Copa de la Reina de Balonmano |
| Next: | 2016–17 Copa de la Reina de Balonmano |
The 2015–16 Copa de la Reina de Balonmano was the 37th edition of the Copa de la Reina de Balonmano. The tournament began in November 2015 with First round matches, following Second round to finish with the Final8.
The Final8 took place in O Porriño, Galicia, from 15 to 17 April. The matches will be played at Pavillón Polideportivo de Porriño, with 2,500 capacity seating. It was hosted by Federación Galega de Balonmán, Xunta de Galicia, O Porriño concello & RFEBM. O Porriño hosted Copa de la Reina for the last time in 2013.
Bera Bera won its fifth title after defeating newcomer's Prosetecnisa Zuazo in the Final 33–17.
| Round | Date | Fixtures | Clubs | Notes | |
|---|---|---|---|---|---|
| First round[1] | 21–22 November 2015 | 6 | 12 → 6 | 6 top teams from 2014–15 División de Plata + 6 bottom teams from 2014–15 División de Honor gain entry. | |
| Second round[2] | 20 February 2016 | 6 | 12 → 6 | 6 top teams from 2014–15 División de Honor's teams gain entry. | |
| Final8[3] | 15–17 April 2016 | 7 | 8 → 1 | Rocasa G.C. ACE (defending champions) and BM Porriño (host team) gain entry. |
|}
| Teams qualified to Second Round | |||
|---|---|---|---|
| Aiala Zarautz | Jofemesa Oviedo | Clínicas Rincón Málaga | |
| KH-7 Granollers | Sporting La Rioja | Mavi Nuevas Tecnologias LC | |
|}
| Teams qualified to Final8 | |||
|---|---|---|---|
| Sporting La Rioja | Helvetia Alcobendas | Prosetecnisa Zuazo | |
| Bera Bera | Mecalia Atl. Guardés | Clínicas Rincón Málaga | |
------------
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| Rank | Name | Team | Goals |
|---|---|---|---|
| 1 | Laura Steinbach | Prosetecnisa Zuazo | 28 |
| 2 |  Ana Isabel Martínez | BM Bera Bera | 17 |
| 3 | Elisabeth Pinedo | BM Bera Bera | 13 |
| 4 | Soraia Lopes | BM Porriño | 13 |
| 5 | Haridian Rodríguez | Rocasa G.C. ACE | 12 |