| Champ: |  Kei Nishikori |
| Runner: | Ivo Karlović |
| Score: | 6–4, 7–6(7–0) |
| Draw: | 32 |
| Seeds: | 8 |
| Type: | singles doubles |
| Before Name: | U.S. National Indoor Tennis Championships – Men's singles |
| After Name: | Memphis Open |
| Main Name: | U.S. National Indoor Championships |
See main article: 2014 U.S. National Indoor Tennis Championships.
Kei Nishikori was the defending champion and successfully defended his title, defeating Ivo Karlović in the final, 6–4, 7–6(7–0).
The top four seeds receive a bye into the second round.
See also: 1. 
David Goffin (qualified)
See also: 2. 
Denis Kudla (qualified)
See also: 3. Alex Kuznetsov (qualified)
See also: 4. 
Víctor Estrella Burgos (qualifying competition)
See also: 5. Rajeev Ram (qualified)
See also: 6. Gastão Elias (qualifying competition)
See also: 7. Bobby Reynolds (qualifying competition)
See also: 8. 
James McGee (qualifying competition)