| Champ: |  Jo-Wilfried Tsonga |
| Runner: | Roger Federer |
| Score: | 7–5, 7–6(7–3) |
See main article: 2014 Rogers Cup.
Jo-Wilfried Tsonga defeated Roger Federer in the final, 7–5, 7–6(7–3) to win the men's singles tennis title at the 2014 Canadian Open. Tsonga became the first man to defeat Novak Djokovic, Andy Murray, and Federer in the same tournament since Rafael Nadal at the 2008 Hamburg Masters.
Rafael Nadal was the reigning champion, but withdrew due to a right-wrist injury.
The top eight seeds receive a bye into the second round.
See also: 1 and 1. 
Novak Djokovic (third round)
See also: 2 and 4. Roger Federer (final)
See also: 3 and 2. Stan Wawrinka (third round)
See also: 4 and 3. 
Tomáš Berdych (third round)
See also: 5 and 4. 
David Ferrer (quarterfinals)
See also: 6 and 3. 
Milos Raonic (quarterfinals)
See also: 7 and 2. Grigor Dimitrov (semifinals)
See also: 8 and 1. 
Andy Murray (quarterfinals)
See also: 9. 
(withdrew because of a right foot injury)
See also: 10 and 4. 
John Isner (first round)
See also: 11 and 3. Ernests Gulbis (second round)
See also: 12 and 1. Richard Gasquet (third round, withdrew because of an abdominal strain)
See also: 13 and 1. Jo-Wilfried Tsonga (champion)
See also: 14 and 3. Roberto Bautista Agut (first round)
See also: 15 and 4. Marin Čilić (third round)
See also: 16 and 2. 
Fabio Fognini (second round)
See also: 17 and 2. Tommy Robredo (third round)
See also: 1. 
Marinko Matosevic (qualifying competition, retired,)
See also: 2. Benjamin Becker (first round)
See also: 3. Bernard Tomic (qualified)
See also: 4. Tobias Kamke (qualified)
See also: 5. Matthew Ebden (first round)
See also: 6. Benoît Paire (qualified)
See also: 7. Tim Smyczek (qualified)
See also: 8. 
Malek Jaziri (qualifying competition, lucky loser)
See also: 9. Yūichi Sugita (qualifying competition)
See also: 10. Michael Russell (qualified)
See also: 11. James Duckworth (qualifying competition)
See also: 12. Vincent Millot (qualifying competition)
See also: 13. Michaël Llodra (qualifying competition)
See also: 14. Thanasi Kokkinakis (qualified)