The knockout stages of the 2014 Copa do Brasil were played from August 27 to November 26, 2014. A total of 16 teams competed in the knockout stages.
A draw by CBF was held on August 18 to set the matches for this round. The 16 qualified teams were divided in two pots. Teams from pot 1 are the ones who competed at the 2014 Copa Libertadores plus the two highest CBF ranked teams qualified via the Third Round. Pot 2 is composed of the other teams that qualified through the Third Round. Each pot was divided into 4 pairs according to the CBF ranking. That division makes sure that each team within a pair will not face each other before the finals as they will be placed in opposite sides of the bracket. There was a draw to decide the home team of the round of 16. The following stages will have other draws to determine the order of the matches as the tournament advances.[1]
The first legs will be played on August 27–28 and the second legs will be played on September 3–4, 2014.[2]
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----Santos advanced directly due to Grêmio's disqualification.
----Tied 5–5 on aggregate, Botafogo won on away goals.
----Cruzeiro won 7–1 on aggregate.
----ABC won 3–2 on aggregate.
----Tied 3–3 on aggregate, Flamengo won 3–2 on penalties.
----América won 3–2 on aggregate.
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Atlético Mineiro won 3–0 on aggregate.
----Corinthians won 3–2 on aggregate.
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----Santos won 8–2 on aggregate.
----Tied 3–3 on aggregate, Cruzeiro won on away goals.
----Flamengo won 2–0 on aggregate.
----Atlético Mineiro won 4–3 on aggregate.
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----Cruzeiro won 4–3 on aggregate.
----Atlético Mineiro won 4–3 on aggregate.
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----Atlético Mineiro won 3–0 on aggregate.