| Date: | 8–14 September 2014 |
| Edition: | 27th |
| Surface: | Hard |
| Location: | Istanbul, Turkey |
| Champs: |  Adrian Mannarino |
| Champd: |  Colin Fleming / Jonathan Marray |
| Before Name: | American Express – TED Open |
The 2014 Amex-Istanbul Challenger was a professional tennis tournament played on hard courts. It was the 27th edition of the tournament which was part of the 2014 ATP Challenger Tour. It took place in Istanbul, Turkey between 8 and 14 September 2014.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Tobias Kamke | 73 | 1 | ||
 Tunisia | Malek Jaziri | 88 | 2 | |
| France | Adrian Mannarino | 89 | 3 | |
 Japan | Tatsuma Ito | 126 | 4 | |
| Japan | Yūichi Sugita | 128 | 5 | |
| United Kingdom | James Ward | 131 | 6 | |
| Jimmy Wang | 132 | 7 | ||
 Turkey | Marsel İlhan | 144 | 8 |
The following players received wildcards into the singles main draw:
Barış Ergüden Cem İlkel Barkın Yalçınkale Anıl YükselThe following players received entry from the qualifying draw:
See main article: 2014 Amex-Istanbul Challenger – Singles.
Adrian Mannarino def. Tatsuma Ito, 6–0, 2–0, ret.See main article: 2014 Amex-Istanbul Challenger – Doubles.
Colin Fleming / Jonathan Marray def. 
Jordan Kerr / Fabrice Martin, 6–4, 2–6, [10–8]
