| Date: | 28 October – 3 November |
| Edition: | 9th |
| Surface: | Clay |
| Location: | Montevideo, Uruguay |
| Champd: | Martín Cuevas / Pablo Cuevas |
The 2013 Uruguay Open was a professional tennis tournament played on clay courts. It was the ninth edition of the tournament, which was part of the 2013 ATP Challenger Tour. It took place in Montevideo, Uruguay between October 28 and November 3, 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Leonardo Mayer | 82 | 1 | |
 Italy | Paolo Lorenzi | 86 | 2 | |
| Argentina | Diego Sebastián Schwartzman | 105 | 3 | |
 Colombia | Alejandro González | 108 | 4 | |
 Brazil | Rogério Dutra da Silva | 127 | 5 | |
 Spain | Pere Riba | 133 | 6 | |
| Argentina | Martín Alund | 133 | 7 | |
| Spain | ||||
| Argentina | Facundo Bagnis | 139 | 9 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw via protected ranking:
The following players received entry as a special exempt into the singles main draw:
The following players received entry from the qualifying draw:
The following players received entry into the singles main draw as a lucky loser:
See main article: 2013 Uruguay Open – Singles.
Thomaz Bellucci def. Diego Sebastián Schwartzman 6–4, 6–4See main article: 2013 Uruguay Open – Doubles.
André Ghem / Rogério Dutra da Silva Walkover