| Champ: |  John Isner |
| Runner: |  Nicolás Almagro |
| Score: | 6–3, 7–5 |
| Type: | singles doubles |
See main article: 2013 U.S. Men's Clay Court Championships. Juan Mónaco was the defending champion, but lost to John Isner in the semifinals.
Isner went on to win the title, defeating Nicolás Almagro in the final, 6–3, 7–5.
The top four seeds received a bye into the second round.
The top five seeds receive a bye into the second round.