See main article: 2013 Open de Nice Côte d'Azur. Nicolás Almagro was the two-time defending champion but decided not to participate.
Albert Montañés won the title, defeating Gaël Monfils in the final, 6–0, 7–6.(7–3)
The top four seeds received a bye into the second round.
The top four seeds received a bye into the second round.