The 2013 Open de Nice Côte d'Azur was a men's tennis tournament played on outdoor clay courts. It was the 29th edition of the Open de Nice Côte d'Azur and was part of the ATP World Tour 250 series of the 2013 ATP World Tour. It took place at the Nice Lawn Tennis Club in Nice, France, from May 19 through May 25, 2013.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Czech Republic | ||||
 France | Gilles Simon[1] | 17 | 2 | |
| Sam Querrey | 19 | 3 | ||
| John Isner | 20 | 4 | ||
 Italy | Andreas Seppi | 21 | 5 | |
| Italy | Fabio Fognini | 25 | 6 | |
 Spain | ||||
 Uzbekistan | Denis Istomin | 45 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
The following player received entry as an alternate:
Brian Baker Tomáš Berdych (fatigue)
Bernard Tomic (personal reasons) Marcel Granollers (shoulder injury)
Xavier Malisse Benoît Paire
Alejandro Falla (right calf injury)| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
 Pakistan | Aisam-ul-Haq Qureshi | Jean-Julien Rojer | 15 | 1 | ||
 Poland | Mariusz Fyrstenberg | Poland | Marcin Matkowski | 61 | 2 | |
| Eric Butorac | Czech Republic | Lukáš Dlouhý | 83 | 3 | ||
| Italy | Daniele Bracciali | Italy | Potito Starace | 86 | 4 |
The following pairs received wildcards into the doubles main draw:
Pablo Andújar / Albert Ramos Alexandre Massa / Alexandre PiersonThe following pair received entry as alternates:
Alejandro Falla (right calf injury) Albert Montañés defeated Gaël Monfils, 6–0, 7–6(7–3)
Johan Brunström / Raven Klaasen defeated Juan Sebastián Cabal / Robert Farah, 6–3, 6–2
