The 2013 Internazionali Femminili di Palermo was a professional women's tennis tournament played on outdoor clay courts. It was the 26th edition of the tournament which was part of the 2013 WTA Tour. It took place in Palermo, Italy between 8 and 14 July 2013.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Italy | Sara Errani | 5 | 1 | |
| Italy | Roberta Vinci | 11 | 2 | |
 France | Kristina Mladenovic | 37 | 3 | |
 Czech Republic | Klára Zakopalová | 43 | 4 | |
 Spain | Lourdes Domínguez Lino | 53 | 5 | |
 Romania | Irina-Camelia Begu | 61 | 6 | |
| Spain | Silvia Soler Espinosa | 74 | 7 | |
| Czech Republic | Karolína Plíšková | 77 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Alexandra Dulgheru (right toe injury)| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| France | Kristina Mladenovic |  Poland | Katarzyna Piter | 131 | 1 | |
 Slovakia | Janette Husárová | Spain | Silvia Soler Espinosa | 131 | 2 | |
| Czech Republic | Renata Voráčová | Czech Republic | Barbora Záhlavová-Strýcová | 137 | 3 | |
| Mirjana Lučić-Baroni | Czech Republic | Klára Zakopalová | 146 | 4 |
The following pairs received wildcards into the doubles main draw:
See main article: 2013 Internazionali Femminili di Palermo – Singles.
Roberta Vinci def. Sara Errani, 6–3, 3–6, 6–3See main article: 2013 Internazionali Femminili di Palermo – Doubles.
Kristina Mladenovic / Katarzyna Piter def. Karolína Plíšková / Kristýna Plíšková, 6–1, 5–7, [10–8]
