| Champ: |  Bob Bryan Mike Bryan |
| Runner: |  Mahesh Bhupathi Rohan Bopanna |
| Score: | 6–2, 6–3 |
See main article: 2013 Italian Open (tennis). Marcel Granollers and Marc López were the defending champions, but lost to Santiago González and Scott Lipsky in the quarterfinals.
Bob Bryan and Mike Bryan won the title, defeating Mahesh Bhupathi and Rohan Bopanna in the final, 6–2, 6–3.
All seeds receive a bye into the second round.