The women's 4 x 50 metre medley relay at the 2013 IPC Swimming World Championships was held at the Parc Jean Drapeau Aquatic Complex in Montreal from 12 to 18 August.
| Points | width=200 bgcolor=gold | Gold | width=200 bgcolor=silver | Silver | width=200 bgcolor=CC9966 | Bronze |
| 20 points | Oksana Khrul S6 Nataliia Prologaieva SB4 Olena Fedota S6 Olga Sviderska S3 | Anastasia Didorova S6 Ulyana Kuznetsova SB7 Alexandra Agafonova S3 Irina Kolmogorova S4 | Alyssa Gialamas S5 Noga Nir-Kistler SB5 Reilly Boyt S6 Cheryl Angelelli S4 |