The men's 4 x 50 metre freestyle relay at the 2013 IPC Swimming World Championships was held at the Parc Jean Drapeau Aquatic Complex in Montreal from 12–18 August.
| Points | width=200 bgcolor=gold | Gold | width=200 bgcolor=silver | Silver | width=200 bgcolor=CC9966 | Bronze |
| 20 pts[1] | Ronystony Cordeiro da Silva S4 Adriano de Lima S6 Clodoaldo Silva S5 Daniel Dias S5 | Iaroslav Semenenko S6 Eskender Mustafaiev S4 Dmytro Vynohradets S3 Yevheniy Bohodayko S7 | Dmitrii Kokarev S2 Andrey Gladkov S7 Aleksei Lyzhikhin S4 Sergey Sukharev S7 |