| Champ: | Sabine Ellerbrock |
| Runner: | Jiske Griffioen |
| Score: | 6–3, 3–6, 6–1 |
See main article: 2013 French Open.
Sabine Ellerbrock defeated Jiske Griffioen in the final, 6–3, 3–6, 6–1 to win the women's singles wheelchair tennis title at the 2013 French Open.
Esther Vergeer was the six-time reigning champion, but retired from professional wheelchair tennis in February 2013. Since Vergeer had won every edition of the event since its creation in 2007, a new French Open singles champion was guaranteed.