The knock-out stage of the 2013 CAF Champions League was played from 5 October to 10 November 2013. A total of four teams competed in the knock-out stage.[1]
The winners and runners-up of each of the two groups in the group stage qualified for the knock-out stage.
| Group | width=190 | Winners | width=190 | Runners-up |
|---|---|---|---|---|
| A |  Al-Ahly | Orlando Pirates | ||
| B |  Espérance de Tunis |  Coton Sport |
Knock-out ties were played on a home-and-away two-legged basis. If the sides were level on aggregate after the second leg, the away goals rule was applied, and if still level, the tie proceeded directly to a penalty shoot-out (no extra time was played).[1]
The schedule of each round was as follows.[2]
| Round | First leg | Second leg | |
|---|---|---|---|
| Semi-finals | 4–6 October 2013 | 18–20 October 2013 | |
| Final | 1–3 November 2013 | 8–10 November 2013 |
In the semi-finals, the group A winners played the group B runners-up, and the group B winners played the group A runners-up, with the group winners hosting the second leg.[1]
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2–2 on aggregate. Al-Ahly won the penalty shoot-out and advanced to the final.----1–1 on aggregate. Orlando Pirates won on the away goals rule and advanced to the final.
See main article: 2013 CAF Champions League Final.
In the final, the order of legs was decided by a draw.[3] The draw was held on 14 May 2013, 14:00 UTC+2, at the CAF Headquarters in Cairo, Egypt.
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Al-Ahly won 3–1 on aggregate.