The 2013 Brussels Open was a women's tennis tournament played on outdoor clay courts. It was the third and last edition of the Brussels Open, and was part of the Premier-level tournaments of the 2013 WTA Tour. The event took place at the Royal Primerose Tennis Club in Brussels, Belgium, from May 18 through May 25, 2013.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Caroline Wozniacki | 9 | 1 | ||
 Italy | Roberta Vinci | 15 | 2 | |
 Slovakia | Dominika Cibulková | 16 | 3 | |
| Sloane Stephens | 17 | 4 | ||
 Belgium | Kirsten Flipkens | 21 | 5 | |
| Julia Görges | 25 | 6 | ||
| Varvara Lepchenko | 31 | 7 | ||
 China | Peng Shuai | 38 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
 India | Sania Mirza | China | Zheng Jie | 35 | 1 | |
| Anna-Lena Grönefeld |  Czech Republic | Květa Peschke | 42 | 2 | ||
| Chan Hao-ching | Darija Jurak | 78 | 3 | |||
 Belarus | Olga Govortsova |  Poland | Alicja Rosolska | 108 | 4 |
The following pair received a wildcard into the doubles main draw:
Kaia Kanepi def. Peng Shuai, 6–2, 7–5 Květa Peschke def. 
Gabriela Dabrowski / 
Shahar Pe'er, 6–0, 6–3
