| Score: | 7–5, 6–4 |
| Draw: | 64 (4 / 3) |
| Seeds: | 16 |
See main article: 2012 Wimbledon Championships. Serena and Venus Williams defeated Andrea Hlaváčková and Lucie Hradecká in the final, 7–5, 6–4 to win the ladies' doubles tennis title at the 2012 Wimbledon Championships.[1] It was the Williams sisters' fifth Wimbledon title together, and their 13th major doubles title together overall.
Květa Peschke and Katarina Srebotnik were the defending champions, but lost in the second round to Francesca Schiavone and Flavia Pennetta.
See also: 1 and 1. 
Liezel Huber / Lisa Raymond (semifinals)
See also: 2 and 4. 
Sara Errani / Roberta Vinci (quarterfinals)
See also: 3 and 3. 
Květa Peschke / Katarina Srebotnik (second round)
See also: 4 and 2. 
Maria Kirilenko / Nadia Petrova (second round)
See also: 5 and 1. Ekaterina Makarova / Elena Vesnina (quarterfinals)
See also: 6 and 4. Andrea Hlaváčková / Lucie Hradecká (final)
See also: 7 and 2. 
Yaroslava Shvedova / Galina Voskoboeva (third round)
See also: 8 and 3. Iveta Benešová / Barbora Záhlavová-Strýcová (second round)
See also: 9 and 3. 
Nuria Llagostera Vives / María José Martínez Sánchez (quarterfinals)
See also: 10 and 2. Raquel Kops-Jones / Abigail Spears (quarterfinals)
See also: 11 and 4. Natalie Grandin / Vladimíra Uhlířová (third round)
See also: 12 and 1. Anabel Medina Garrigues / Arantxa Parra Santonja (first round)
See also: 13 and 2. Bethanie Mattek-Sands / 
Sania Mirza (third round)
See also: 14 and 4. 
Gisela Dulko / Paola Suárez (first round)
See also: 15 and 3. Irina-Camelia Begu / Monica Niculescu (second round, retired)
See also: 16 and 1. Chuang Chia-jung / Vera Dushevina (first round)
See main article: 2012 Wimbledon Championships – Women's doubles qualifying.