See main article: 2012 Valencia Open 500. Marcel Granollers was the defending champion, but lost to Alexandr Dolgopolov in the quarterfinals.
David Ferrer won the title, defeating Dolgopolov in the final, 6–1, 3–6, 6–4.
Former world No. 1 Juan Carlos Ferrero played his last match at the tournament losing to 6th seed Nicolás Almagro in the first round in straight sets.