The 2012 VTR Open was a men's tennis tournament play on outdoor clay courts. It was the 19th edition of the VTR Open, and was part of the ATP World Tour 250 series of the 2012 ATP World Tour. It took place in Viña del Mar, Chile from January 28 through February 5, 2012. After two editions hosted in Santiago, the event returned to Viña del Mar.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Juan Mónaco | 27 | 1 | |
| Juan Ignacio Chela | 29 | 2 | ||
 Brazil | Thomaz Bellucci | 37 | 3 | |
 Spain | Pablo Andújar | 45 | 4 | |
| Spain | Albert Montañés | 50 | 5 | |
 Colombia | Santiago Giraldo | 56 | 6 | |
| Argentina | Carlos Berlocq | 61 | 7 | |
 Italy | Filippo Volandri | 72 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Tommy Robredo (leg injury)| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Brazil | André Sá | Brazil | Bruno Soares | 77 | 1 | |
| Juan Sebastián Cabal | Robert Farah | 103 | 2 | |||
| Spain | David Marrero | Pere Riba | 164 | 3 | ||
| Spain | Pablo Andújar | Carlos Berlocq | 173 | 4 |
The following pairs received wildcards into the doubles main draw:
See main article: 2012 VTR Open – Singles. Juan Mónaco defeated Carlos Berlocq, 6–3, 6–7(1–7), 6–1
See main article: 2012 VTR Open – Doubles. Frederico Gil / Daniel Gimeno-Traver defeated Pablo Andújar / Carlos Berlocq, 1–6, 7–5, [12–10]