| Champ: |  Juan Mónaco |
| Runner: |  John Isner |
| Score: | 6–2, 3–6, 6–3 |
| Type: | singles doubles |
See main article: 2012 U.S. Men's Clay Court Championships. Ryan Sweeting was the defending champion but lost to John Isner in the quarterfinals. Isner lost in the final to Juan Mónaco, 2–6, 6–3, 3–6.
The top four seeds receive a bye into the second round.