The 2012 Trophée des Alpilles was a professional tennis tournament played on hard courts. It was the fourth edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Saint-Rémy-de-Provence, France between 3 and 9 September 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Luxembourg | Gilles Müller | 53 | 1 | |
 Italy | Flavio Cipolla | 87 | 2 | |
 Belgium | Olivier Rochus | 105 | 3 | |
| Matthias Bachinger | 115 | 4 | ||
 Russian Federation | Evgeny Donskoy | 119 | 5 | |
| Russian Federation | Igor Kunitsyn | 126 | 6 | |
 France | Josselin Ouanna | 147 | 7 | |
| Gastão Elias | 148 | 8 |
The following players received wildcards into the singles main draw:
Antoine Escoffier Adrian Mannarino Elie Rousset Martin VaisseThe following players received entry from the qualifying draw:
Guillermo Olaso Florian Reynet
David RiceSee main article: 2012 Trophée des Alpilles – Singles.
Josselin Ouanna def. Flavio Cipolla, 6–4, 7–5See main article: 2012 Trophée des Alpilles – Doubles.
Laurynas Grigelis / 
Uladzimir Ignatik def. Jordi Marsé-Vidri / Carles Poch Gradin, 6–7(4–7), 6–3, [10–6]