| Champ: |  Nadia Petrova |
| Runner: |  Agnieszka Radwańska |
| Score: | 6–0, 1–6, 6–3 |
| Type: | singles doubles |
| Draw: | 56 (8 / 3) |
| Seeds: | 16 |
| Before Name: | Toray Pan Pacific Open – Singles |
| After Name: | Toray Pan Pacific Open – Singles |
| Main Name: | Pan Pacific Open |
See main article: 2012 Toray Pan Pacific Open.
Nadia Petrova defeated the defending champion Agnieszka Radwańska in the final, 6–0, 1–6, 6–3 to win the singles tennis title at the 2012 Pan Pacific Open.
The top eight seeds receive a bye into the second round.
Andrea Hlaváčková