The 2012 Tiburon Challenger was a professional tennis tournament played on hard courts. It was the sixth edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Tiburon, California, United States between October 8 and October 14, 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Benjamin Becker | 85 | 1 | ||
| James Blake | 97 | 2 | ||
| Ryan Sweeting | 136 | 3 | ||
| Wayne Odesnik | 137 | 4 | ||
 Italy | Matteo Viola | 146 | 5 | |
| Tim Smyczek | 153 | 6 | ||
| Denis Kudla | 160 | 7 | ||
| Bobby Reynolds | 162 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry as a special exempt into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2012 Tiburon Challenger – Singles.
Jack Sock def. Mischa Zverev, 6–1, 1–6, 7–6(7–3)See main article: 2012 Tiburon Challenger – Doubles.
Chris Guccione def. Jordan Kerr / 
Andreas Siljeström, 6–1, 6–4