| Year: | 2012 |
| Team: | Southern Illinois Salukis |
| Sport: | football |
| Conference: | Missouri Valley Football Conference |
| Short Conf: | MVFC |
| Record: | 6–5 |
| Conf Record: | 5–3 |
| Head Coach: | Dale Lennon |
| Hc Year: | 5th |
| Off Coach: | Kalen DeBoer |
| Oc Year: | 3rd |
| Def Coach: | Bubba Schweigert |
| Dc Year: | 3rd |
| Stadium: | Saluki Stadium |
The 2012 Southern Illinois Salukis football team represented Southern Illinois University Carbondale as a member of the Missouri Valley Football Conference (MVFC) during the 2012 NCAA Division I FCS football season. Led by fifth-year head coach Dale Lennon, the Salukis compiled an overall record of 6–5 with a mark of 5–3 in conference play, placing in a three-way tie for third in the MVFC. Southern Illinois played home games at Saluki Stadium in Carbondale, Illinois.