The 2012 Serbia Open (also known as Serbia Open 2012 powered by Telekom Srbija for sponsorship reasons) was a men's tennis tournament play on outdoor clay courts. The fourth edition of the event was hosted by Serbian player Novak Djokovic. It was part of the ATP World Tour 250 series of the 2012 ATP World Tour. It took place at the Tennis Center Novak complex in Belgrade, Serbia, from 28 April through 6 May 2012. Andreas Seppi won the singles title.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Spain | Pablo Andújar | 38 | 1 | |
 Italy | Andreas Seppi | 46 | 2 | |
 Finland | Jarkko Nieminen | 47 | 3 | |
 Argentina | David Nalbandian | 49 | 4 | |
 Poland | Łukasz Kubot | 51 | 5 | |
| Italy | Fabio Fognini | 57 | 6 | |
 United States | Ryan Harrison | 58 | 7 | |
 Luxembourg | Gilles Müller | 61 | 8 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
Novak Djokovic (personal reasons) Dušan Lajović (ankle injury)| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
 Sweden | Robert Lindstedt |  Romania | Horia Tecău | 17 | 1 | |
| Scott Lipsky | Rajeev Ram | 92 | 2 | |||
 Israel | Jonathan Erlich | Andy Ram | 97 | 3 | ||
| United States | James Cerretani | Adil Shamasdin | 129 | 4 |
The following pairs received wildcards into the doubles main draw:
David Nalbandian (fatigue)See main article: 2012 Serbia Open – Singles. Andreas Seppi defeated 
Benoît Paire, 6–3, 6–2
See main article: 2012 Serbia Open – Doubles. Jonathan Erlich / Andy Ram defeated Martin Emmrich / Andreas Siljeström, 4–6, 6–2, [10–6]
