The 2012 Seguros Bolívar Open Bucaramanga was a professional tennis tournament played on clay courts. It was the fourth edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Bucaramanga, Colombia between 23 and 29 January 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 France | Éric Prodon | 96 | 1 | |
 Italy | Paolo Lorenzi | 109 | 2 | |
 Argentina | Horacio Zeballos | 111 | 3 | |
 Romania | Adrian Ungur | 116 | 4 | |
| Argentina | Máximo González | 124 | 5 | |
| Wayne Odesnik | 128 | 6 | ||
| Paul Capdeville | 130 | 7 | ||
 Brazil | Júlio Silva | 151 | 8 |
The following players received wildcards into the singles main draw:
Juan Sebastián Gómez Máximo González Felipe MantillaThe following players received entry from the qualifying draw:
See main article: 2012 Seguros Bolívar Open Bucaramanga – Singles. 
Wayne Odesnik def. Adrian Ungur 6–1, 7–6(7–4)
See main article: 2012 Seguros Bolívar Open Bucaramanga – Doubles. Ariel Behar / Horacio Zeballos def. 
Miguel Ángel López Jaén / Paolo Lorenzi, 6 - 4, 7 - 6(7 - 5)
