The 2012 Save Cup was a professional tennis tournament played on clay courts. It was the tenth edition of the tournament which is part of the 2012 ITF Women's Circuit. It took place in Mestre, Italy between 3 and 10 September 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Julia Cohen | 101 | 1 | ||
 Italy | Karin Knapp | 129 | 2 | |
| Italy | Alberta Brianti | 132 | 3 | |
 Austria | Yvonne Meusburger | 137 | 4 | |
 Spain | Estrella Cabeza Candela | 145 | 5 | |
| Italy | Nastassja Burnett | 153 | 6 | |
| Anastasija Sevastova | 162 | 7 | ||
 Poland | Marta Domachowska | 180 | 8 |
The following players received wildcards into the singles main draw:
Giulia Bruschi Julia Mayr
Yuliana Lizarazo Anna RemondinaThe following players received entry from the qualifying draw:
Marina Melnikova
Teodora MirčićThe following players received entry by a lucky loser spot:
See main article: 2012 Save Cup – Singles.
Karin Knapp def. Estrella Cabeza Candela, 6–1, 3–6, 6–1See main article: 2012 Save Cup – Doubles.
Mailen Auroux / María Irigoyen def. 
Réka-Luca Jani / Teodora Mirčić, 5–7, 6–4, [10–8]